Who We Are
We just followed our curiosity about the brain. Starting with informal gatherings, we began reading papers and reference books on neuroscience, first with tempting keywords: perception, memory, mind and consciousness. We are now down to earth with neurons, synapses, and neuronal networks. We look for the fundamental rules govern the brain dynamics in different scales. Ultimate goal is still up to the sky and we are still curious.
Structral and Functional Brain
10 July 2019
Structural and Functional Brain Networks: From Connections to Cognition
Why brain does have change? while its structural brain is invariant. Introduction of functional and effective brain may answer to this fundamental question.
The aim of this paper is to give us a fully description on the hierarchical functional and effective brain.
Hippocampal theta rhythm and its...
24 June 2019
Peer Wulffa,1, Alexey A. Ponomarenkob,1, Marlene Bartosa...
Hippocampal theta (5–10 Hz) and gamma (35–85 Hz) oscillations depend on an inhibitory network of GABAergic interneurons. How- ever, the lack of methods for direct and cell-type-specific interference with inhibition has prevented better insights that help link synaptic and cellular properties with network function. Here, we generated genetically modified mice (PV-2) in which synaptic inhibition was ablated..
The roll of fast synaptic inhibition
23 June 2019
Marlene Bartos, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer, Jörg R. P. Geiger,...
Networks of GABAergic interneurons are of critical importance for the generation of gamma frequency oscillations in the brain. To examine the underlying synaptic mechanisms, we made paired recordings from “basket cells” (BCs) in different subfields of hippocampal slices, using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the parvalbumin promoter....
The roll of shunting Inhibition
22 June 2019
Imre Vida, Marlene Bartos, and Peter Jonas2
Networks of GABAergic neurons are key elements in the generation of g oscillations in the brain. Computa- tional studies suggested that the emergence of co- herent oscillations requires hyperpolarizing inhibition. Here, we show that GABAA receptor-mediated inhibi- tion in mature interneurons of the hippocampal den- tate gyrus is shunting rather than hyperpolarizing. Un- expectedly, when shunting inhibition is incorporated into a structured interneuron network
Mechanism of Interneron network
15 June 2019
Marlene Bartos, Imre Vida and Peter Jonas
Gamma frequency oscillations are thought to provide a temporal structure for information processing in the brain. They contribute to cognitive functions, such as memory formation and sensory processing, and are disturbed in some psychiatric disorders. Fast-spiking, parvalbumin-expressing, soma-inhibiting interneurons have a key role in the generation of these oscillations.
Emerson M. Pugh
"If the human brain were so simple that we could understand it, we would be so simple that we couldn’t."
“Swiftly the brain becomes an enchanted loom, where millions of flashing shuttles weave a dissolving pattern always a meaningful pattern. though never an abiding one.”