Research Keywords

Protein aggregation,
Amyloid proteins,
Parkinson disease,
Mitochondrial dysfunction,
Oxidative stress,

Courses

Carbohydrate and lipid

Metabolism regulation

Biochemistry of membrane

Selected Publications

• Mamashli, F., Meratan, A. A., Ghasemi, A., Obeidi, N., Salmani, B., Atarod, D., ... & Saboury, A. A., "Neuroprotective Effect of Propolis Polyphenol-Based Nanosheets in Cellular and Animal Models of Rotenone-Induced Parkinson’s Disease", ACS Chemical Neuroscience, 2023


• Zohoorian-Abootorabi, T., Meratan, A. A., Jafarkhani, S., Muronetz, V., Haertlé, T., & Saboury, A. A. , "Modulation of cytotoxic amyloid fibrillation and mitochondrial damage of α-synuclein by catechols mediated conformational changes", Scientific Reports, 2023


• Sohrabi, T., Mirzaei-Behbahani, B., Zadali, R., Pirhaghi, M., Morozova-Roche, L. A., & Meratan, A. A. , "Common Mechanisms Underlying α-Synuclein-Induced Mitochondrial Dysfunction in Parkinson’s Disease.", Journal of Molecular Biology, 2023


• Rafiei, Y., Salmani, B., Mirzaei-Behbahani, B., Taleb, M., Meratan, A. A., Ramezani, M., ... & Rezaei-Ghaleh, N. , "Polyphenols-Based Nanosheets of Propolis Modulate Cytotoxic Amyloid Fibril Assembly of α-Synuclein", ACS Chemical Neuroscience, 2022


• Zadali, R., Hassani, V., Rafiei, Y., Meratan, A. A., Mamashli, F., & Nemat-Gorgani, M., "A study on the interaction of the amyloid fibrils of α-synuclein and hen egg white lysozyme with biological membranes", Biochimica et Biophysica Acta (BBA)-Biomembranes, 2022


• Meratan, A. A., Hassani, V., Mahdavi, A., & Nikfarjam, N., "Pomegranate seed polyphenol-based nanosheets as an efficient inhibitor of amyloid fibril assembly and cytotoxicity of HEWL", RSC Advances, 2022


• Ramezani, M., Hesami, M. D., Rafiei, Y., Ghareghozloo, E. R., Meratan, A. A., & Nikfarjam, N., "Efficient amyloid fibrillation inhibition and remodeling of preformed fibrils of bovine insulin by propolis polyphenols-based nanosheets.", ACS Applied Bio Materials, 2021


• Dehghani, Z., Meratan, A. A., Saboury, A. A., & Nemat-Gorgani, M. , "α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease", Biochimica et Biophysica Acta (BBA)-Biomembranes, 2020


• Rostampour Ghareghozloo, E., Mahdavimehr, M., Meratan, A. A., Nikfarjam, N., Ghasemi, A., Katebi, B., & Nemat-Gorgani, M, "Role of surface oxygen-containing functional groups of graphene oxide quantum dots on amyloid fibrillation of two model proteins", PLOS ONE, 2020


• Zadali, R., Ghareghozloo, E. R., Ramezani, M., Hassani, V., Rafiei, Y., Chiyaneh, S. M., & Meratan, A. A., "Interactions with and membrane permeabilization of brain mitochondria by amyloid fibrils", Journal of Visualized Experiments, 2019


• Mahdavimehr, M., Katebi, B., & Meratan, A. A. , "Effect of fibrillation conditions on the anti-amyloidogenic properties of polyphenols and their involved mechanisms.", International journal of biological macromolecules, 2018


• Katebi, B., Mahdavimehr, M., Meratan, A. A., Ghasemi, A., & Nemat-Gorgani, M., "Protective effects of silibinin on insulin amyloid fibrillation, cytotoxicity and mitochondrial membrane damage", Archives of biochemistry and biophysics, 2018


• Mahdavimehr, M., Meratan, A. A., Ghobeh, M., Ghasemi, A., Saboury, A. A., & Nemat-Gorgani, M. , "Inhibition of HEWL fibril formation by taxifolin: mechanism of action", PLOS ONE, 2017


• Ghobeh, M., Ahmadian, S., Meratan, A. A., Ebrahim‐Habibi, A., Ghasemi, A., Shafizadeh, M., & Nemat‐Gorgani, M., "Interaction of Aβ (25–35) fibrillation products with mitochondria: Effect of small‐molecule natural products.", Peptide Science, 2014


• Meratan, A. A., & Nemat-Gorgani, M., "Mitochondrial membrane permeabilization upon interaction with lysozyme fibrillation products: role of mitochondrial heterogeneity.", Biochimica et Biophysica Acta (BBA)-Biomembranes, 2012


• Meratan, A. A., Ghasemi, A., & Nemat-Gorgani, M. , "Membrane integrity and amyloid cytotoxicity: a model study involving mitochondria and lysozyme fibrillation products", Journal of molecular biology, 2011