Cancer is one of the leading causes of human death on the globe and scientists around the world are working together to have a deeper knowledge of this disease and find new and better ways for its prevention, diagnosis and treatment. My research has different perspectives as an integrated research plan in cancer biology. One research area that I am interested in is developing the CRISPR systems that provide us with the ability to perform massive high throughput screenings in a more reliable, efficient and informative way; and then use these systems in functional genomics to find the genes involved in cancer cell survival or their resistance to the drugs. This approach is accompanied with molecular cloning, computational biology and functional studies to acquire the list of the candidate genes that are involved in our process of interest. Enlisted candidate genes can serve as potential targets for cancer therapy and are subjected to follow up studies to discover methods to target them with small molecules or gene therapy. Another research area of my interest is cancer signaling. Although high throughput screenings are able to provide a substantial amount of the unbiased data, signaling studies, with their detailed structure, can use the accumulated knowledge of the cancer biology to understand the role of a specific protein in tumor formation and growth. This type of the research helps us to have a better insight into the basic mechanisms of human cell biology as well as the mechanisms underlying tumor formation. And last but not the least is the cancer genetics that I am attracted to. Cancer genetics is important from different points of view since it can be helpful in both prevention and treatment of cancer. Knowing the genetic alternations/variations that lead to a special type of cancer and the follow up research to understand how a particular genetic alternation/variation cause cancer formation can help us to define novel methods for cancer prevention and therapy.
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