Description

I am Shiva Akbari Birgani, the assistant professor, Department of Biochemistry, Faculty of Life Sciences, at Institute of Advanced Studies in Basic Sciences (IASBS). I have Ph.D. and MSc of Biochemistry. I received my Ph.D. from Tarbiat Modarres University. My Ph.D. thesis was the study of cardiomyocytic differentiation of mouse embryonic stem cells (mESCs) and its comparison with apoptosis at the molecular level. My thesis was under the supervision of Professor Saman Hosseinian from Tarbiat Modarres University and Professor Hossein Baharvand from  Royan Institute.
The main focus of my research team at IASBS is the study of cancer. One of my interests is understanding the molecular mechanism determining cell fate. To take advantage of this knowledge in gene therapy and curing cancer. The other interest is the development of a suitable three-dimensional cancer model that we can use to study our proposed therapeutic approaches in conditions closer to the human body.
ResearchGate link; Shiva Akbari-Birgani on ResearchGate
Research projects and students
1- Design and development of biosensors for real-time detection of cell death and cancer stem cells
MSc Students; Roya Mokhtar, Najmeh Kiani, Zahra Madadi, Amir Hossein Esmaili, Tahereh Sohrabi
2- Comparative study of differentiation and apoptosis
MSc Students; Zahra Madadi, Fatemeh Hakim, Razieh Khatami
3- Drug delivery using Nano / micro materials
MSc Students;  Masoud Mohseni, Parviz Davoodi
4- Development of 3D breast cancer models
MSc Students;  Sahar Moradi Mehr, Erfan Sefidgar
Ph.D. student; Farzaneh Fallahi

Research interests

Cancer; Breast cancer, Acute myeloid leukemia (AML), Neuroblastoma
Differentiation and Apoptosis
Development of three-dimensional tumor models

Courses

Molecular biology

Programmed cell death

Publications

Shiva Akbari-Birgania,b,*, Mitra Khademya, Masoud Mohseni Dargaha, Zahra Madadia, Roya Mokhtar Ahmadabadia, Parviz Davoodi Monfareda. , "Caspases interplay with kinases and phosphatases to determine cell fate. ", European Journal of Pharmacology, 1, 2019, doi: 10.1016/j.ejphar.2019.04.048

Mokhtar-Ahmadabadi R, Madadi Z, Akbari-Birgani S, Grillon C, Hasani L, Hosseinkhani S, Zareian S., "Developing a circularly permuted variant of Renilla luciferase as a bioluminescent sensor for measuring Caspase-9 activity in the cell-free and cell-based systems.", Biochemical and Biophysical Research Communications, 2018, doi: 10.1016/j.bbrc.2018.11.009.

Mohammadi S, Akbari-Birgani S, Borji M, Kaboudin B, Vaezi M., "Diethyl [(3-phenoxy-2-oxo-4-phenyl-azetidin-1-yl)-phenyl-methyl]-phosphonate as a potent anticancer agent in chemo-differentiation therapy of acute promyelocytic leukemia.", European Journal of Pharmacology, 2019, doi: 10.1016/j.ejphar.2019.01.003

Mohseni-Dargah M, Akbari-Birgani S, Madadi Z, Saghatchi F, Kaboudin B., "Carbon nanotube-delivered iC9 suicide gene therapy for killing breast cancer cells in vitro.", Nanomedicine, , doi: 10.2217/nnm-2018-0342

Akbari-Birgani S, Paranjothy T, Zuse A, Janikowski T, Cieślar-Pobuda A, Likus W, Urasińska E, Schweizer F, Ghavami S, Klonisch T, Łos MJ., "Cancer stem cells, cancer-initiating cells and methods for their detection.", Drug Discov Today, 2016, doi: 10.1016/j.drudis.2016.03.004

Akbari-Birgani S, Hosseinkhani S, Mollamohamadi S, Baharvand H., "Delay in apoptosome formation attenuates apoptosis in mouse embryonic stem cell differentiation.", J Biol Chem, 2014, doi: 10.1074/jbc.M113.536730

Mohammadi S, Ghaffari SH, Shaiegan M, Zarif MN, Nikbakht M, Akbari Birgani S, Alimoghadam K, Ghavamzadeh A., "Acquired expression of osteopontin selectively promotes enrichment of leukemia stem cells through AKT/mTOR/PTEN/β-catenin pathways in AML cells.", Life Sci., 2016, doi: 10.1016/j.lfs.2016.04.003

Madadi, Z., Akbari-Birgani, S*., Davoodi-Monfared, P., Mohammadi, S., "The non-apoptotic role of caspase-9 promotes differentiation in leukemic cells.", Biochim Biophys Acta Mol Cell Res, 08, 2019, doi: 10.1016/j.bbamcr.2019.118524